Chrysin is a naturally occurring flavonoid with mild anticancer activity. In this paper\nwe report the synthesis of new chrysin derivatives alkylated with N-phenylchloroacetamides in\nposition 7. A novel method was developed for the preparation of 7-aminochrysin derivatives via\nthe Smiles rearrangement, resulting in diphenylamine-type compounds. In silico studies of the\nSmiles rearrangement were performed. We also present the in vitro antiproliferative activity of the\nsynthesized compounds against 60 human tumor cell lines (NCI60). The most potent derivative\nexhibited nanomolar antitumor activity on the MCF7 cell line of breast cancer (GI50 = 30 nM) and on\nthe HCT-15 cell line of colon cancer (GI50 = 60 nM).
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